IFAR - Multisite Systemic Pain -Is Pain Affecting Multiple Areas of Your Body_ copy

Is Pain Affecting Multiple Areas of Your Body?

Systemic or multisite pain can develop after trauma, surgery, cancer treatment, or nerve injury. It often feels widespread, unpredictable, and resistant to typical therapies. Whether your pain radiates through multiple limbs, affects mobility, or causes ongoing fatigue and sensitivity, our surgeons are here to help.

Our team at The Institute takes a multidisciplinary approach that combines advanced diagnostics, nerve reconstruction, and microsurgical expertise to provide lasting relief for even the most complex pain syndromes.

You don’t have to live this way. Here’s who we help:

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Individuals living with pain that travels between multiple areas of the body, such as the neck, back, and legs.
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Patients with persistent nerve pain following cancer treatment, trauma, or radiation.
IFAR - Icon - Amputees or limb-salvage patients struggling with neuroma or phantom limb pain. copy
Amputees or limb-salvage patients struggling with neuroma or phantom limb pain.
IFAR - ICON -People with chronic swelling, nerve compression, or pain that worsens with movement. copy
People with chronic swelling, nerve compression, or pain that worsens with movement.
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Patients who have been told there are no surgical options for their chronic pain.
"Lovely doctor. I explained my pain I was having after another operation. She listened, assessed and treated the issue perfectly. Follow up was easy as well and I adore her staff. Highly recommend."
— Mike, Patient of Dr. Ferro
"Dr Nicole Ferro is the best Dr at pain management, I highly recommend her for pain management over any other doctor"
— Lakhias, Patient of Dr. Ferro
"I first met Dr Ferro for upper and lower back pain in Novenber 2024. She knew exactly where to press to trigger the pains I was feeling. Dr Ferro spent a lot of time with me and was very thorough. Fast forward to April 2025. I had trigger point injections with Dr Ferro, then came back 2 weeks later for lower back injections performed in the ambulatory center. I was a little nervous both times but her nurse Angela, made me feel so relaxed. Angela also answered my questions the few times I contacted the office to ask questions. She is very professional and caring. Overall, Dr Ferro is very professional, caring and understands that back pain can be overwhelming. She only wants to best outcome."
— Jennifer, Patient of Dr. Ferro
"I’ve been living with chronic shoulder pain for 15 years following a car accident in 2010. My shoulder was in constant spasm, and after trying off-label medications, injections that didn’t work, and being dismissed by other doctors, I resigned myself to daily pain. Dr. Ferro was the first doctor who truly listened and took my pain seriously. She understood how chronic pain had been affecting my life and created a targeted treatment plan to address the root of the issue. After receiving functional Botox injections under her care, I am pain free for the first time in 15 years. It still feels surreal to say that. I also want to thank Natalie, Dr. Ferro’s surgical coordinator. The insurance process wasn’t easy, but Natalie went above and beyond to advocate for me. She made what could have been an overwhelming experience feel more human and personal, and I’m incredibly grateful for that. I cannot thank Dr. Ferro and her team enough."
— Lauren, Patient of Dr. Ferro
"DrFerro is an amazing, kind, caring, and very gentle doctor. She truly cares about her patients. I shout her praises, and highly recommend her; you will be blessed to make an appointment, and become pain free:)))"
— Karol, Patient of Dr. Ferro
"Dr. Ferro and her team are very compassionate and caring about managing my pain."
— Susan, Patient of Dr. Ferro
"Dr Ferro and her nurse are OUTSTANDING....I have Medicaid and have seen doctors that are rude and don't help.. SHE IS THE COMPLETE OPPOSITE... caring.. professional...listens to you...and absolutely cares.. IF YOU ARE IN PAIN... GO SEE HER SHE WILL DO ALL SHE CAN TO HELP YOU "
— Joe, Patient of Dr. Ferro
"I have been blessed to have met some of the finest doctors that I have ever met in my life. At the age of 62 you would think that’s pretty hard to say it’s not It’s the truth. Dr Shah, Dr. Ferro have been nothing but an ace in the hole not only for myself, but for my whole family. I have been suffering for quite some time with Nerve injuries and while other doctors are clinical Dr Shah and Dr. Ferro act on their word, and deliver 100% of devotion, in order to help you succeed in the process of healing. If you ever need a doctor, you’re suffering with horrific nerve pain look no further they deliver."
— J, Patient of Dr. Ferro

Conditions We Treat

Patients with multisite or systemic pain often experience symptoms that cross regional boundaries and involve multiple body systems. Our team evaluates the full picture to identify the underlying source of pain and develop a plan that targets both function and long-term relief.
Nerve and Neuropathic Causes
Structural and Musculoskeletal Causes
Post-Surgical and Post-Treatment Causes
Reconstructive and Systemic Conditions

Nerve and Neuropathic Causes

Multisite pain often results from widespread nerve injury, neuropathy, or chronic pain syndromes that affect multiple regions of the body. Learn more about:

Structural and Musculoskeletal Causes

Degenerative or multi-joint disorders can produce widespread stiffness and pain, limiting mobility across several body regions. Learn more about:

Post-Surgical and Post-Treatment Causes

Chronic pain that affects multiple areas of the body can develop after surgery, trauma, or cancer treatment due to nerve damage or tissue fibrosis. Learn more about:

Reconstructive and Systemic Conditions

Comprehensive reconstructive and nerve procedures can restore function, improve appearance, and relieve pain that impacts multiple regions or systems. Learn more about:

ground-breaking

Advanced Procedures That Relieve Chronic Pain

Our surgical team uses advanced microsurgical and reconstructive techniques to address systemic pain that affects, restoring comfort, movement, and quality of life.
Nerve Reconstruction Surgery
Repairs or reconnects damaged nerves to help restore function, relieve chronic pain, and improve sensation across multiple body areas. Read More
Targeted Muscle Reinnervation (TMR)

Redirects injured or severed nerves into healthy muscles to reduce pain, prevent neuromas, and restore nerve stability.

Read More
Regenerative Peripheral Nerve Interface (RPNI)

Uses small muscle grafts to protect and stabilize nerves, reducing chronic pain and improving long-term comfort.

Read More
Nerve Grafts
Bridges or replaces damaged nerve sections to reestablish healthy communication between the brain and affected body regions. Read More
Joint Denervation

Interrupts pain signals from arthritic or damaged joints while maintaining normal mobility and function.

Read More
Decompression Surgery
Releases entrapped or compressed nerves to relieve chronic or radiating pain throughout the body. Read More
Reconstructive Surgeries

Repairs tissue and nerve damage across multiple regions to restore balance, alignment, and long-term comfort.

Limb Salvage

Preserves and reconstructs limbs affected by trauma or poor circulation, helping to prevent amputation and relieve pain.

Read More
FLAP Surgery (DIEP / TRAM / Free Flap Reconstruction)

Transfers healthy tissue to reconstruct areas affected by trauma or surgery, restoring contour and improving blood flow.

Read More
Fat Grafting

Restores soft tissue and relieves pain by adding cushioning around nerves damaged by trauma, surgery, or radiation.

Read More
Wound Debridement / Complex Wound Care

Removes damaged or infected tissue to promote healing, reduce inflammation, and relieve pain from chronic wounds.

Read More
Lymphedema Surgery
Improves fluid drainage and reduces swelling, helping patients regain comfort and movement in affected regions. Read More
Pressure Sore Management
Repairs and reconstructs skin and soft tissue affected by pressure ulcers to relieve pain and promote healing. Read More

Why Patients Choose The Institute When Others Can’t Help

Global Leaders in Surgical Pain Management

Chronic pain care requires more than symptom control. It demands deep diagnostic insight, advanced surgical skill, and a commitment to helping patients reclaim their lives. Whether you’ve been searching for answers for months or years, our team offers a unique blend of science, skill, and empathy to help you take back control of your life.

Patients trust The Institute because we provide:

unmatched-icon
Nationally recognized specialists in pain and reconstruction
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Groundbreaking surgical techniques backed by published research
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Expertise in rare and complex nerve conditions
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Collaborative care from multidisciplinary teams
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Personalized treatment plans
proven-outcome
Proven outcomes for patients who’ve exhausted other options
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IFAR - Multisite Systemic Pain -Why Patients Choose The Institute When Others Can’t Help (3) copy
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35
Nerve Surgeries
Performed
20
Peer-Reviewed
Studies Published
250
Global Patients
Served
12
Years Pioneering
Microsurgical Techniques

Want to know how our breakthroughs translate into better outcomes?

See How We’re Changing Lives

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Meet Our Surgeons

Behind every successful surgery is a surgeon who understands the complexity of systemic pain. Our nationally recognized microsurgeons bring unparalleled expertise and a deep commitment to restoring comfort, mobility, and quality of life for every patient.

Michael Rose

Andrew Elkwood

MD, MBA, FACS
Michael Rose

Hamid Abdollahi

MD, FACS
Michael Rose

Peter Andrawes

MD
Michael Rose

Beth Anglin

MD, FACS
Michael Rose

Gary Arishita

MD
Michael Rose

Russell Ashinoff

MD, FACS
Michael Rose

Sean Boutros

MD, FACS
Michael Rose

Anjeanette Brown

MD, FACS
Michael Rose

David Cabiling

MD
Michael Rose

Courtney Carpenter

MD
Michael Rose

Stephen Chagares

MD
Michael Rose

Eric I. Chang

MD, FACS
Michael Rose

Ann Chuang

MD, FACS
Michael Rose

Frank Ciminello

MD, FACS
Michael Rose

Kari L. Colen

MD, FACS
Michael Rose

Ryan Couvillion

MD
Michael Rose

Desiree D'Angelo

DO, FACS
Michael Rose

Joseph Dayan

MD, MBA
Michael Rose

Frank Dellacroce

MD
Michael Rose

George Dreszer

MD
Michael Rose

Stephen Dudick

MD
Michael Rose

Rodion Erenburg

MD
Michael Rose

Berry Fairchild

MD
Michael Rose

Adam Feintisch

MD
Michael Rose

Nicole Ferro

DO
Michael Rose

James Fletcher

MD
Michael Rose

Anton Fries

MD, PhD
Michael Rose

James Frost

MD, FACS
Michael Rose

Amon-Ra Gama

MD
Michael Rose

Andrew Gassman

MD
Michael Rose

Patrick Greaney

MD, FACS
Michael Rose

Ritwik Grover

MD, FACS
Michael Rose

Edward Hahn

MD
Michael Rose

Sanaz Harirchian

MD
Michael Rose

Cassie Hartline

MD
Michael Rose

Sean Herman

MD, FACS
Michael Rose

Zuhaib Ibrahim

MD, FACS
Michael Rose

Lisa Iucci

DO, FACS
Michael Rose

Hari Iyer

MD, FAAOS
Michael Rose

Priya Jadeja

MD, FACS
Michael Rose

Reza Jarrahy

MD, FACS, FAAP
Michael Rose

Santosh Kale

MD, MBA
Michael Rose

Karen Kaplan

MD
Michael Rose

Matthew Kaufman

MD, FACS
Michael Rose

Ergun Kocak

MD
Michael Rose

Arjuna Kuperan

MD
Michael Rose

Chris Lakhiani

MD, FACS
Michael Rose

Peter Ledoux

MD
Michael Rose

Matthew Lynch

MD
Michael Rose

Tyler Merceron

MD
Michael Rose

Ahmed Nasser

MD
Michael Rose

Chet Nastala

MD
Michael Rose

Robert T. Nevitt III

MD
Michael Rose

Oscar Ochoa

MD
Michael Rose

William Ordoyne

MD
Michael Rose

Lauren Otaguro

MD
Michael Rose

Tushar Patel

MD, FACS
Michael Rose

Steven Pisano

MD
Michael Rose

Vaishali Purohit

MD
Michael Rose

Sidney Rabinowitz

MD, FACS
Michael Rose

Deepak Ramesh

MD
Michael Rose

David Rayfield

MD
Michael Rose

Rukmini Rednam

MD
Michael Rose

Michael Rose

MD, FACS
Michael Rose

Adam Saad

MD, FACS
Michael Rose

Nirvana Saraswat

MD
Michael Rose

Ali Seckin

MD, MBA
Michael Rose

Ajul Shah

MD, FACS
Michael Rose

Tzvi Small

MD, FACS
Michael Rose

Mohit Sood

DO
Michael Rose

Scott Sullivan

MD
Michael Rose

Yolanda Tammaro

MD
Michael Rose

Pankaj Tiwari

MD
Michael Rose

Stephen Toran

MD
Michael Rose

Christopher Trahan

MD
Michael Rose

David Tsai

MD, FACS
Michael Rose

Hakan Usal

MD
Michael Rose

Eric Weiss

MD
Michael Rose

Jonathan Weiswasser

MD, FACS
Michael Rose

Lauren Whipple

MD
Michael Rose

Eric Wimmers

MD, FACS
Michael Rose

Whitten Wise

MD
Michael Rose

Mary Jo Wright

MD
Michael Rose

Alex Xu

MD
Michael Rose

Mark Yazid

MD, FACS
Michael Rose

Sarosh Zafar

MD

Your Questions, Answered

Who is a candidate for surgery to relieve systemic or multisite pain?

Patients with chronic, multi-region pain that has not improved with conservative care may be candidates. Our team evaluates each case individually.

→ Learn more about becoming a patient.

Can nerve surgery help if I have pain in several areas at once?

Yes. When the underlying cause involves multiple injured or compressed nerves, surgical repair or decompression can provide lasting relief.

Do I need a referral to be seen at The Institute?

No referral is required. You can contact us directly, though we collaborate closely with referring physicians and specialists.

→ For provider-specific referral information, visit our Referrals page.

How long is recovery from systemic nerve surgery?

Recovery varies by procedure and the number of sites treated, but most patients experience steady improvement in pain and mobility.

Does insurance cover these procedures?

Many of our surgeries are medically necessary and covered by insurance. Our financial coordinators will confirm your coverage before treatment.

Can these procedures treat pain from prior surgeries or cancer treatment?

Yes. We frequently treat patients who develop widespread pain after surgery, chemotherapy, or radiation. Our goal is to repair nerves and restore tissue health.

What makes The Institute different from other pain centers?

We are one of the few centers worldwide that offers advanced surgical solutions for multisite and systemic pain, with outcomes recognized internationally.

→ Learn more about why patients choose us.

What to Expect When You Reach Out

We know reaching this point has likely been a long journey. That’s why we make the next step clear and supportive.

1 Consultation

Share your history and symptoms with our specialized team, either virtually or in-person.

2 Evaluation

Our advanced diagnostic tools and extensive expertise help us understand your condition fully.

3 Personalized Care Plan

You’ll leave with a clear explanation of your options and what recovery could look like.

4 Surgery & Support

If surgery is right for you, our team guides you through every step: before, during, and after.
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Get Relief From Chronic Pain

You do not have to live with pain that affects multiple areas of your body. Our specialists provide advanced care that helps patients finally reclaim comfort and independence.